癌症肿瘤个体化治疗 分享到
Individualized Approach in Fighting Tumors 2017-10-2659026

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Instead of the traditional invasive and painful method for retrieving tissue suspected of being malignant,the new method called liquid biopsy can reliably find tumor cells in the patient’s blood.But just looking at those cells does not tell the whole story.
取代传统的侵入性和痛苦的方法来提取恶性组织细胞,这种新的方法称为液体活检,可以可靠地发现肿瘤细胞在病人的血液中。虽然只看那些细胞并不能说明全部问题。
So the new way to get a diagnosis is to look deep in the cell and understand precisely what made it into tumor and that’s genomic sequencing.
因此,获得诊断的新方法是深入观察细胞,并准确地知道是什么使它进入肿瘤,即基因组测序。
In practical terms genomic sequencing involves making a detailed analysis of the patient’s genome.Looking for mutations that cause the uncontrolled growth of cells into tumors.Once the results are available, doctors comprising a so called tumor board, gather to discuss the best approach to treating that specific patient.The traditional therapy would have involved surgery and chemotherapy or radiation but after genomic sequencing,cancer patient Allison Cannes was treated only with two drugs.
实际上,基因组测序包括对病人的基因组进行详细的分析。寻找导致肿瘤细胞失控生长的突变。一旦结果出来,医生组成一个肿瘤研讨小组,一起讨论如何最佳的方法来治疗特定的病人。传统的治疗方法包括手术、化疗或放疗,但在基因组测序之后,癌症患者埃里森只接受了两种药物治疗。
In about 8 weeks from a treatment the imaging showed about 50% reduction of a tumor and that remains be continued to shrink gradually after the first reduction over the past year now, almost a year now.
在治疗后的大约8周内,影像显示肿瘤缩小约50%,而在过去的一年中,第一次减少后,仍在继续萎缩,现在已经差不多过了一年了。
Some oncologists caution that the biology of cancer is very complicated and that there’s still a lot to learn about it.
一些肿瘤学家警告说,癌症的生物学是非常复杂的,还有很多东西要学。
We’ve actually learned in some these situations where the mutations existed in the genetic analysis and the drug was available to match that genetic mutation.In those patients, it didn’t work.
事实上,我们已经在某些情况下了解到了基因分析中存在的突变,而这种药物可以与基因突变相匹配。对那些病人来说,这种方法不起作用。
Others feel much more optimistic saying they expect tumor profiling to become standard for all cancer patients.So do patients who have experienced improvement in their health.
另一些人则更乐观地说,他们希望肿瘤治疗能成为癌症患者的标准治疗方案。那些经历过健康改善的病人也是这样想。
Boy, if you can, if you can get the DNA testing and there’s a match for it, I’d really high recommend that, because it works so well.
嗬,如果可行的话的话,如果你做了DNA测试,并匹配的话,我真强烈建议你用这种方法,因为真的很好。
George Putic, VOA News, Washington.
美国之音,George Putic华盛顿报道。

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