新研究解释酒精如何损伤干细胞 分享到
New Research Shows How Alcohol Damages Stem Cells 2018-01-0959436

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Maybe you ring in the New Year with one to many.
你也许会和三两或一群好友来共同庆祝新年,
Maybe you just keep it to a glass of wine at night with dinner.
或者在晚餐中用一杯酒来庆祝。
New research suggests that alcohol intake can lead to permanent genetic damage.
新的研究表明,酒精摄入会导致永久性的遗传损伤。
A missing part of the whole puzzle is how precisely alcohol causes damage to usand what our research shows is that alcohol as it’s being processed by the bodyand converted into energy transiently accumulates as a toxin which attacks DNA in a fundamental mannerand damages the genetic information that constitutes the code of life.
整个谜题最重要的部分是酒精如何对我们造成损伤我们的研究表明,酒精在被身体加工并转化为能量瞬间积累成毒素,而这种毒素能从根本上攻击DNA并破坏构成生命代码的遗传信息。
The toxin is called acetaldehyde.
该毒素被称为乙醛,
It is produced when the body processes alcohol and research suggests it can damage human cells in a fundamental way.
它是在人体加工酒精时产生的,研究表明它可以从根本上破坏人体细胞。
This can happen at the level of an a very important cell type known as the stem celland that’s important because the stem cell is a cell that goes on to make many different types of cellsand it’s the regenerating cell in our bodies.
这个反应可能发生在干细胞上,而干细胞是一种极其重要的细胞,是能够制造其他人体细胞类型的再生细胞。
And all that genetic damage can do harm even deadly harm to the human body.
因此所有这些遗传损伤都可能对人体造成伤害,这种伤害甚至是致命的。
We showed that the chromosomes from these blood cells are fundamentally alteredand this is important because altered chromosomes or alter altered DNA is the basis ofwhy cells ultimately gone to age or accumulate the changes that make them cancerous.
我们发现这些血细胞上的染色体从根本上被改变了,这会导致严重的后果,因为是染色体或DNA的改变造成细胞的最终衰老或积聚使其癌变。
The body has an enzyme that breaks down acetaldehyde.
人体有一种分解乙醛的酶。
Patel tested what alcohol does to cells without it.
帕特尔测试了如果没有这种酶,酒精会对细胞产生什么影响。
Say in mice when we take away the enzyme that clears the toxin as well as this DNA repair pathway.Then very small amounts of alcohol cause violent damage to the cells that produce blood.
当拿走小白鼠体内能够清除毒素以及修复DNA的酶,。我们发现极少量的酒精就会对造血细胞造成严重的损伤。
Also most people have a range of DNA repair systems,but Patel says binge drinking can overwhelm those lines of defense and do serious genetic damage.
尽管大多数人体内也都有一系列的DNA修复系统,但帕特尔说酗酒依旧可以压倒这些防线,造成严重的遗传损伤。
Carol Pearson VOA news Washington
美国之音Carol Pearson华盛顿为您报道

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