脑肿瘤新疗法 分享到:
Using Polio To Treat Brain Cancer 2018-07-0144689

双击原文单词查看解释

“How many fingers? Three. How many? Two.”
这是几根手指?三根。现在呢?两根。
Eight years ago, Stephanie Hopper was diagnosed with glioblastoma, an aggressive brain cancer.Surgeons removed the tumor but it returned two years later. The survival rate for glioblastoma is low, at best a year and a half after diagnosis. Hopper entered a study that uses a genetically modified polio virus developed at Duke Cancer Institute. The modified virus doesn’t cause paralysis but it does shrink the tumor. A clinical trial showed the treatment significantly improved the long-term survival rate for patients whose glioblastoma returned. The three year survival rate was 21 percent for these patients, while only four percent of patients at Duke with the same type of recurring brain tumors were alive three years after having what was the standard treatment. Even a dead polio virus causes a very strong immune response the dead virus is used in the polio vaccine. Dr. Darell Bigner is the senior author of the study.
八年前,斯蒂芬妮·霍珀被诊断为胶质母细胞瘤,这是一种恶性脑癌。虽然当时做外科手术切除了肿瘤,但两年后又复发了。患胶质母细胞瘤的病人存活率很低,最多活不过确诊后一年半的时间。霍珀参加了一项由杜克癌症研究所研发的项目,研究所开发了一种转基因脊髓灰质炎病毒。这种经过基因修饰的病毒不会导致瘫痪,但它确实会缩小脑肿瘤。临床试验表明,该疗法显著提高了胶质细胞瘤复发患者的长期生存率。这些患者的3年生存率是百分之二十一,而杜克大学里接受标准治疗的同样类型复发性脑瘤患者中只有百分之四的人能存活三年。即使是灭活的脊髓灰质炎病毒也会引起非常强烈的免疫反应,灭活病毒常被用于脊髓灰质炎疫苗。达雷尔·比格纳博士是这项研究的资深作者。
“What this did, very simply, was to destroy the ability of the polio virus to infect nerve cells and cause poliomyelitis any longer, but it retained the ability to kill cancer cells.”
它的作用非常简单,就是摧毁脊髓灰质炎病毒感染神经细胞并致其发病的能力,但病毒保留了杀死癌细胞的能力。
Doctors injected the modified virus directly into the brain, they repeated the treatment on five patients whose cancer returned.
医生们将这种经过改良的病毒直接注射到大脑中,他们再次对5名癌症复发患者进行了治疗。
“Those that we’ve been able to follow long enough have responded to the treatment the second time.”
那些我们能追踪的足够久的人对第二次治疗做出了反应。
The procedure is still experimental, but the results are so promising. That doctors have started a second study combining the polio virus with chemotherapy to try to improve the results.As for Stephanie Hopper her tumor continues to shrink.
这一过程仍处于试验阶段,但结果很有希望。医生们已经开始了第二项结合脊髓灰质炎病毒和化疗的研究,试图改善结果。至于斯蒂芬妮·霍珀,她的肿瘤继续缩小。
Carol Pearson VOA News.
VOA记者卡罗尔·皮尔森报道。

点击加载更多