声波是否能打破大脑对阿尔茨海默症药物设置的屏障 分享到:
Can Soundwaves Crack the Brain’s Barrier to Alzheimer’s Meds? 2018-08-0154678

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Work with mice at Imperial College London has shown that high-frequency sound waves deliver through a contactgel in the same way ultrasound is used on pregnant women can open parts of the blood-brain barrier.So you can think of it as a kind of gateway or border patrol,that is saying the brain needs glucose that’s allowed in all the foreign pathogens.You’re stopped at the door. You’re not allowed to come into the brain.Researchers inject micro bubbles into the blood stream and targeted sound waves make them vibrate,causing cells in the blood vessel walls to flex to allow drugs to pass through into the brain.
在伦敦帝国理工学院所进行的老鼠试验表明,高频声波通过接触凝胶传递,就像对孕妇使用超声波可以打开其部分血脑屏障一样。因此,你可以将其看作门户或边境的巡逻队,大脑需要葡萄糖,而这些葡萄糖也能为外来病原体所容。被阻挡在门口,就不能进入到大脑中。研究人员在血液中注入微小的气泡,靶向定位的声波使其震动,导致血管壁中的细胞弯曲,让药物通过大脑。
Similar research is being conducted at Sunnybrook Health Sciences Centre in Toronto.Alzheimer’s patient Rick Karr is part of a small trial to see whether specially targeted sound waves could break a temporary hole in the blood-brain barrier.The experiment Rick Karr and five other Alzheimer’s patients shows the barrier opened, let some harmless dye seep in and then sealed back up.Just took two ultrasound treatments to show that the blood-brain barrier can be opened. It’s very exciting.I feel quite emotional about it because there’s a lot riding on this and it’s a whole new world of possibilities, but we have to take one step at a time. We have to make it safe, sure it’s safe.
多伦多的Sunnybrook健康研究中心也进行过相似的研究。阿尔茨海默症的患者Rick Karr这项试验的参与人员之一,来探究特殊的靶向声波是否能够暂时在血脑屏障上打开一个缺口。在对Rick Karr和其他五位阿尔茨海默症的患者进行的试验中,屏障打开,使得一些无害的染料渗入,最后又密封起来。仅仅两次的超声波的治疗就表明了血脑屏障是可以打开的。这令人十分激动。对此,我激动不已,因为我们还有很长的路要走,这是一个全新的充满可能性的世界,但我们必须一步一步来。我们必须保证安全,确保安全。
Once MRIscans pinpoint the desired brain location, researchers beam what’s called focused ultrasound right at that spot.Further innovations will allow even more precise targeting.We can create these complex arrays where we can create multiple beam patterns.We can make large beams, small beams.We can steer the beamto any location in the brain. So the technology so advanced at this point where we can actually deliver the drug to any region of the brain if we can design the transducer you know in a particular way.Any likelihood of a therapy is a long way off, but with the burden of dimension growing in many societies around the world,the need for a solution is driving scientists to explore every possible approach.
一旦核磁共振成像扫描确定了期望的大脑位置,研究人员就会在此位置发出所谓的聚焦超声波。如果进一步创新,我们能够实现更精确的靶向定位。我们可以创建复杂的阵列,在阵列上创建多个光束模式。我们可以制造大光束、小光束。我们可以将光束引导到大脑的任何位置。所以,科技是如此先进,我们可以将药物传输到大脑的任何区域,如果我们可以用特定的方式设计传感器。任何治疗阿尔茨海默症的方法都还有很长的路要走,但是随着世界各地的社会负担不断增加,解决此问题的需求正推动着科学家探索各种可能治疗此病的方法。
I’m Faith Lapidus VOA news.
美国之音新闻,我是Faith Lapidus。

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